Autophagy
| PAG Title | Autophagy |
| PAG ID | WIG001841 |
| Type | P |
| Source Link |  Spike |
| Publication Reference | NA |
| PAG Description | Autophagy, or “self eatingÂ‿, is the process by which de novo-formed double-membrane enclosed vesicles, known as autophagosomes, engulf cytosolic components and organelles, and ultimately fuse with the lysosome, enabling degradation of its internal contents. Autophagy serves as a means of recycling critical cellular building blocks, especially in times of deprivation and stress, and removal of damaged organelles, and misfolded and aggregated proteins. The various stages of autophagosome formation are mediated by the Atg genes, and induction of autophagy is modulated by several signaling pathways and regulators. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 1,412 |
| Information Content | Rich |
| Other IDs | SPIKE00015 |
| Base PAG ID | WIG001841 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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